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Search Results for ""
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of 511 results
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| Abraham, Anub A, Instructor, CL in
Medicine-Hospital Medicine
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| Address: |
Rubloff Building
Suite
11-187
750 N Lake Shore
Chicago, IL 60611
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| Phone: |
312/503-2338
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Adam, Stephen A, Assoc Prof in
Cell and Molecular Biology
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| E-mail: |
s-adam@northwestern.edu |
| Address: |
Ward Building
Room
11-201
303 E Chicago Avenue
Chicago IL, 60611
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| Phone: |
312-503-7525
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| Interests: |
Cell Biology
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| Descriptive Phrases: |
nuclear transport, nuclear structure, nuclear pore complex, nuclear envelope, nuclear lamins
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| Selected Publications: |
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Selected PubMed Publications
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Regulation of nuclear lamin polymerization by importin alpha.
Adam SA, Sengupta K, Goldman RD
The Journal of biological chemistry 2008 Mar 28; 283(13):8462-8
PMID: 18227062
Grant Support:
5 R01 CA 031760-25/CA/NCI NIH HHS
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A mitotic lamin B matrix induced by RanGTP required for spindle assembly.
Tsai MY, Wang S, Heidinger JM, Shumaker DK, Adam SA, Goldman RD, Zheng Y
Science (New York, N.Y.) 2006 Mar 31; 311(5769):1887-93
PMID: 16543417
Grant Support:
CA31760-24/CA/NCI NIH HHS
GM56312/GM/NIGMS NIH HHS
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A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis.
Geles KG, Johnson JJ, Jong S, Adam SA
Molecular biology of the cell 2002 Sep; 13(9):3138-47
PMID: 12221121
Grant Support:
GM-47866/GM/NIGMS NIH HHS
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Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.
Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y
Science (New York, N.Y.) 2001 Jan 26; 291(5504):653-6
PMID: 11229403
Grant Support:
GM47866/GM/NIGMS NIH HHS
GM53678/GM/NIGMS NIH HHS
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| Adams, James G, Professor in
Emergency Medicine
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| E-mail: |
emchair@nmff.org |
| Address: |
Room
100
NMH/259 E Erie
Chicago, IL 60611
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| Phone: |
312-694-7000
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| Phone: |
312-926-2289
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| Interests: |
Emergency Medicine; Patient Safety; Ethics of Research with Human Subjects; Healthcare Quality; Communications
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| Descriptive Phrases: |
Ethics, professionalism and communication in the healthcare setting.
Achieving measurable efficacy, safety, efficiency and satisfaction in a complex healthcare delivery system.
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| Selected Publications: |
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Selected PubMed Publications
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Patient perspectives on communication with the medical team: pilot study using the Communication Assessment Tool-Team (CAT-T).
Mercer LM, Tanabe P, Pang PS, Gisondi MA, Courtney DM, Engel KG, Donlan SM, Adams JG, Makoul G
Patient education and counseling 2008 Nov; 73(2):220-3
PMID: 18703306
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Knowledge translation of the American College of Emergency Physicians clinical policy on hypertension.
Lehrmann JF, Tanabe P, Baumann BM, Jones MK, Martinovich Z, Adams JG
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2007 Nov; 14(11):1090-6
PMID: 17898244
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Refining Emergency Severity Index triage criteria.
Tanabe P, Travers D, Gilboy N, Rosenau A, Sierzega G, Rupp V, Martinovich Z, Adams JG
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2005 Jun; 12(6):497-501
PMID: 15930399
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Defining and evaluating professionalism: a core competency for graduate emergency medicine education.
Larkin GL, Binder L, Houry D, Adams J
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2002 Nov; 9(11):1249-56
PMID: 12414479
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Selected Books and Book Chapters
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Adams JG, editor.
2008.
Adams Emergency Medicine.
Philadelphia: Elsevier 2274.
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Adams JG, editor.
2006.
Rosens Emergency Medicine, Marx, Hockberger, Walls, Executive Editors.
Philadelphia: Elsevier 3180.
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| Adams, Mary A, Asst Prof, Emer in
Pediatrics
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| Address: |
Evanston Northwestern Healthcare
2650 Ridge
Evanston IL, 60201
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| Adeyemi, Oluwadamilola A, Instructor, CL in
Medicine-Infectious Diseases
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| Address: |
Suite
900
645 N Michigan Avenue
Chicago, IL 60611
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| Phone: |
312/695-5085
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| Interests: |
AIDS; HIV Infection; Infectious Diseases
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| Descriptive Phrases: |
Global Health/International Health, Tropical Medicine
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| Selected Publications: |
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Selected PubMed Publications
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Multiple brain abscesses due to Actinomyces species.
Adeyemi OA, Gottardi-Littell N, Muro K, Kane K, Flaherty JP
Clinical neurology and neurosurgery 2008 Sep; 110(8):847-9
PMID: 18603353
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Invasive infections with community-associated methicillin-resistant Staphylococcus aureus after kidney transplantation.
Adeyemi OA, Qi C, Zembower TR, Ison MG, Grant TH, Hartigan BJ, Malczynski M, Stosor V
Journal of clinical microbiology 2008 Aug; 46(8):2809-13
PMID: 18524959
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Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literature.
Adeyemi OA, Yeldandi AV, Ison MG
The AIDS reader 2008 Apr; 18(4):196-8, 201-2, 206-7
PMID: 18472442
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Woman with multiple brain abscesses.
Adeyemi OA, Lie O, Bernstein R, Gottardi-Littell N, Muro K, Patil D, Noskin GA
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 Nov 15; 45(10):1351-2, 1397-9
PMID: 17968834
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| Agrawal, Rishi K, Asst Prof in
Pediatrics
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| Address: |
Children's Memorial Hospital
Box
86
2300 Childrens Plaza
Chicago, IL 60614
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| Phone: |
773/880-4549
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| Interests: |
Health Services Research; Pediatrics; Physician workforce issues
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| Descriptive Phrases: |
The innovation of pediatric specialty clinicians has extended the lives of children with complex medical needs, neurological impairment, and technology dependence. However, our systems of care have diffulty meeting the complex needs of this emerging population. Challenges lie in coordination of care through a vast contiuum that includes hospital systems, primary care, home health, etc. My interests lie in defining this population of patients; studying their needs on a clinical and systems level, and advocating for quality improvement. A new area of focus is the potential for electronic health information exchange, now a national priority, to faciliate the coordination of care for these patients.
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| Allen, Gail A, Instructor, CL in
Pediatrics
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| Address: |
Children's Memorial Hospital
Box
86
2300 Childrens Plaza
Chicago, IL 60614
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| Phone: |
773/880-4549
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Allen, Jeffrey A, Asst Prof in
Ken and Ruth Davee Department of Neurology
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| Address: |
Abbott Hall
Suite
1123
710 N Lake Shore Drive
Chicago, IL 60611
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| Phone: |
312/908-5035
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| Interests: |
Neurology; Electrophysiology
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| Descriptive Phrases: |
Neuropathy, Muscle disease, Myasthenia gravis, Electrophysiology in peripheral nervous system diseases.
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| Selected Publications: |
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Selected PubMed Publications
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Ocular myasthenia gravis in a senior population: Diagnosis, therapy, and prognosis.
Allen JA, Scala S, Jones HR
Muscle & nerve 2009 Nov 13; :
PMID: 19918767
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Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease.
Allen JA, Greenberg SA, Amato AA
Muscle & nerve 2009 Oct; 40(4):643-7
PMID: 19670319
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Muscle atrophy associated with multiple sclerosis: a benign condition or the onset of amyotrophic lateral sclerosis?
Allen JA, Stein R, Baker RA, Royden Jones H
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2008 Jun; 15(6):706-8
PMID: 18395451
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Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
Allen JA, Adlakha A, Bergethon PR
Archives of neurology 2006 Oct; 63(10):1475-8
PMID: 17030665
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| Altshuler, Barry A, Instructor, CL in
Pediatrics
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| Address: |
Children's Memorial Hospital
Box
86
2300 Childrens Plaza
Chicago, IL 60614
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| Phone: |
773/880-4549
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| Alvares, Keith , Res Assoc Prof in
Cell and Molecular Biology
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| E-mail: |
k-alvares@northwestern.edu |
| Address: |
Ward Building
Room
13-320
303 E Chicago Avenue
Chicago IL, 60611
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| Phone: |
312-503-2628
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| Interests: |
Biochemistry: Proteins; Cell Biology; Extracellular Matrix
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| Descriptive Phrases: |
Dentin phosphophoryn (DPP), the major noncollagenous protein of tooth dentin matrix is synthesized as dentin sialophosphoprotein (DSPP) by the mesenchyme-derived odontoblasts. We have found a spatio-temporal expression during mouse embryonic development in cells of epithelial origin. At day-13 of embryonic gestation, DPP was localized to the enamel organ at the developing tooth cap stage, with heaviest immuno-histochemical staining at the oral ectoderm but was also prominent in the inner enamel epithelium. Interestingly, at the same embryonic stage, DPP was also expressed in the ureteric bud branches of the metanephric kidney and in the alveolar epithelial buds of the developing lung. No expression was seen in the mesenchymal component of either organ. Interestingly inclusion of anti-DPP antibodies in E-13 organ cultures of kidneys harvested from wild type mice, altered ureteric bud morphogenesis and caused looseness of the metanephric mesenchyme. These findings suggest that besides its role in mineralization of the dentin, DPP modulates epithelial-mesenchymal interactions in meristic tissues during embryonic development.
Another focus in our laboratory has been studies directed towards understanding the mechanism of mineralization in vertebrate tissues such as bone and tooth and in sea urchin tooth in invertebrates and the role of extracellular constituents of connective tissue in this complex process. The acidic protein constituent part of extracellular matrix has been implicated in mineral deposition but the precise series of molecular reaction mechanism remains undefined. In invertebrate systems, where the mineral part is calcite or aragonite the mechanisms of molecular calcification remains even much less understood compared to vertebrates where mineral deposition is chiefly calcium hydroxyapatite. We are studying whether it is the nature of the protein or environment that determines whether we get Calcium Carbonate or Calcium Phosphate crystals
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| Selected Publications: |
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Selected PubMed Publications
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The proteome of the developing tooth of the sea urchin, Lytechinus variegatus: mortalin is a constituent of the developing cell syncytium.
Alvares K, Dixit SN, Lux E, Barss J, Veis A
Journal of experimental zoology. Part B. Molecular and developmental evolution 2007 Jul 15; 308(4):357-70
PMID: 17385701
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Expression and potential role of dentin phosphophoryn (DPP) in mouse embryonic tissues involved in epithelial-mesenchymal interactions and branching morphogenesis.
Alvares K, Kanwar YS, Veis A
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Nov; 235(11):2980-90
PMID: 16937369
Grant Support:
DE-01374/DE/NIDCR NIH HHS
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Structure and assembly of the heterotrimeric and homotrimeric C-propeptides of type I collagen: significance of the alpha2(I) chain.
Malone JP, Alvares K, Veis A
Biochemistry 2005 Nov 22; 44(46):15269-79
PMID: 16285730
Grant Support:
AR-013921/AR/NIAMS NIH HHS
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Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro.
Tompkins K, Alvares K, George A, Veis A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005 Feb; 20(2):341-9
PMID: 15647828
Grant Support:
DE-08525/DE/NIDCR NIH HHS
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| Ameer, Guillermo A, Assoc Prof in
Surgery-Vascular
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| Address: |
Suite
650
NMH/676 N Saint Clair
Chicago, IL 60611
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| Phone: |
312/926-7775
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An, Gary C, Assoc Prof in
Surgery-Trauma/Critical Care
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| E-mail: |
docgca@aol.com |
| Address: |
Suite
650
NMH/676 N Saint Clair
Chicago, IL 60611
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| Phone: |
312-695-4835
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| Interests: |
Inflammation; Bioinformatics ; Critical Care; Molecular Biology; Drug Discovery; Surgery
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| Descriptive Phrases: |
My research focuses on the utilization of agent-based modeling for multi-scale modeling of acute inflammation. Agent levels include cells and molecules, with the goal of simulating organ- and organism-level behaviors from these generative mechanisms. While the focus of my models have primarily been on the pathophysiology of sepsis and multiple organ failure, in a more general sense I am interested in using agent-based modeling as a means of dynamic knowledge representation to augment the biomedical research process. With respect to acute inflammation, the ubiquitousness of the underlying cellular and molecular mechanisms suggest the application of this methodology to such area as oncogenesis, transplant immunology/rejection, autoimmune disease, wound healing/scarring, atherosclerosis and aging. I am currently using NetLogo as my primary agent-based modeling platform, but am involved with the development of SPARK (Simple Platform for Agent-based Representation of Knowledge http://www.pitt.edu/~cirm/spark/ ) currently being done at the University of Pittsburgh. I am also interested in automated text analysis/information extraction from biomedical texts, formal knowledge representation in biomedicine and the development of methods for evolving biomedical ontologies. These goals form a "front-end" to high-level modeling tools (such as MetaABM http://www.metascapeabm.com/ ) and are intended to facilitate the ability for biomedical knowledge to be represented, communicated and evaluated via executable models. I am also involved in projects directed at developing methods to execute ABMs on massively parallel computing platforms. I believe this is a vital development necessary for true, multi-scale, biologically relevant simulation.
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| Selected Publications: |
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Selected PubMed Publications
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Translational systems biology of inflammation.
Vodovotz Y, Csete M, Bartels J, Chang S, An G
PLoS computational biology 2008 Apr; 4(4):e1000014
PMID: 18437239
Grant Support:
P50-GM-53789-08/GM/United States NIGMS
R01-GM-67240-02/GM/United States NIGMS
R01-HL-76157-02/HL/United States NHLBI
R01-HL080926-01/HL/United States NHLBI
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Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation.
An G
Theoretical biology & medical modelling 2008; 5:11
PMID: 18505587
Grant Support:
H133E070024//United States PHS
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Concepts for developing a collaborative in silico model of the acute inflammatory response using agent-based modeling.
An G
Journal of critical care 2006 Mar; 21(1):105-10; discussion 110-1
PMID: 16616634
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In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling.
An G
Critical care medicine 2004 Oct; 32(10):2050-60
PMID: 15483414
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| Anwar, Khalida A, Instructor in
Physical Medicine and Rehabilitation
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| Address: |
Rehabilitation Institute of Chicago
Room
1436
345 E Superior
Chicago, IL 60611
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| Phone: |
312/238-4637
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| Arana, Flavio A, Instructor, CL in
Psychiatry and Behavioral Sciences
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| Address: |
NMH/Onterie Building
Suite
7-100
446 E Ontario
Chicago, IL 60611
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| Phone: |
312/926-2323
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| Arend, Richard A, Asst Prof in
Psychiatry and Behavioral Sciences
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| Address: |
Children's Memorial Hospital
Box
10
2300 Childrens Plaza
Chicago IL, 60614
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| Ash, Michael A, Instructor, CL in
Medicine-Hospital Medicine
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| Address: |
Rubloff Building
Suite
11-187
750 N Lake Shore
Chicago, IL 60611
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| Phone: |
312/503-2338
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| Aufox, Sharon A, Instructor in
Obstetrics and Gynecology-Reproductive Genetics
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Affiliated Centers:
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Center for Genetic Medicine
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| Address: |
NMH/Prentice Women's Hospital
Room
05-2168
250 E Superior
Chicago, IL 60611
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| Phone: |
312/472-4683
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| Ault, Michael L, Assoc Prof in
Anesthesiology
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| Address: |
NMH/Feinberg
Room
5-704
251 E Huron
Chicago, IL 60611
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| Phone: |
312/926-2280
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| Interests: |
Anesthesiology; Critical Care; Cardiovascular Imaging; Neuroscience ; Undergraduate Medical Education; Resuscitation
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| Descriptive Phrases: |
My current clinical research interests include critical care medicine with a focus on the neurologically injured patient population. However, as Medical Directory of the Northwestern Memorial Hospital Emergency Response Team, I am also interested in the systems analyses of in-hospital resuscitation teams which are being described and investigated using an IRB approved research database. Additionally, as Clerkship Co-Director of the NUFSM ICU M4 Clerkship, I have begun work on investigating the use of patient simulation in undergraduate medical education as an educational adjunct.
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| Selected Publications: |
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Selected PubMed Publications
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Cardiac Troponin I and Acute Lung Injury After Subarachnoid Hemorrhage.
Naidech AM, Bassin SL, Garg RK, Ault ML, Bendok BR, Batjer HH, Watts CM, Bleck TP
Neurocritical care 2009 Apr 30; :
PMID: 19407934
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Monitoring with the Somanetics INVOS 5100C after aneurysmal subarachnoid hemorrhage.
Naidech AM, Bendok BR, Ault ML, Bleck TP
Neurocritical care 2008; 9(3):326-31
PMID: 18360782
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Higher hemoglobin is associated with less cerebral infarction, poor outcome, and death after subarachnoid hemorrhage.
Naidech AM, Drescher J, Ault ML, Shaibani A, Batjer HH, Alberts MJ
Neurosurgery 2006 Oct; 59(4):775-9; discussion 779-80
PMID: 17038943
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The effect of a new NPO policy on operating room utilization.
Murphy GS, Ault ML, Wong HY, Szokol JW
Journal of clinical anesthesia 2000 Feb; 12(1):48-51
PMID: 10773508
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Selected Books and Book Chapters
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Ault ML, Stock MC. Respiratory function in anesthesia. In:
Barash P, Cullen B, Stoelting R, editors.
2009.
Clinical Anesthesia.
Philadelphia: Lippincott Williams & Wilkins 233-255.
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Ault ML, Gould R. Pain control of the critically ill. In:
Benzon HT, Raja SN, Molloy RE, Liu SS, Fishman SM, editors.
2005.
Essentials of Pain Medicine and Regional Anesthesia.
Philadelphia: Churchill Livingstone 271-276.
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Ault ML. Respiratory monitoring. In:
Vender JS, Szokol JW, editors.
2004.
INTERNATIONAL ANESTHESIOLOGY CLINICS. Clnical Monitoring and Transesophageal
Echocardiography Part I.
Philadelphia: Lippincott Williams & Wilkins 97-112.
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Ault ML, Cooper SJ. The preoperative assessment clinic: its value and function. In:
Lumb PD, editor.
1997.
ANESTHESIOLOGY CLINICS OF NORTH AMERICA. Critical Care Medicine in Transition:
The Anesthesiologist's Role.
Philadelphia: W. B. Sauders Company 735-752.
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Backer, Carl , Professor in
Surgery-Cardiothoracic
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Affiliated Centers:
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Feinberg Cardiovascular Research Institute
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| E-mail: |
cbacker@childrensmemorial.org |
| Address: |
Division of Cardiovascular-Surgery
Children's Memorial Hospital
2300 Childrens Plaza mc 22
Chicago IL, 60614
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| Phone: |
773-880-4378
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| Phone: |
773-880-4379
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| Interests: |
Surgery; Arrhythmias; Transplantation; Cardiovascular Diseases; Heart Disease; Pediatrics; Circadian Rhythms; Cardiology
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| Descriptive Phrases: |
Carl L. Backer, MD is the A.C. Buehler Professor of Surgery, Division Head of Cardiovascular-Thoracic Surgery, and Surgical Director of the Cardiac Transplant Program at Children's Memorial Hospital in Chicago. He is a world-renowned pediatric cardiovascular-thoracic surgeon. Dr. Backer specializes in the surgical treatment of congenital heart disease in infants and children and also performs complex re-do procedures in adults. His primary interests are: adults with congenital heart disease, arrhythmia surgery, heart transplantation, vascular ring surgery, tracheal reconstruction, and pacemakers. He has authored or co-authored over 180 refereed articles, 68 book chapters, and 4 textbooks. He is the co-editor of the 2nd and 3rd editions of the well-known textbook, Pediatric Cardiac Surgery.
His research incorporates over 40 years of database material from Children's Memorial Hospital. Future research endeavors will focus on cardiac stem cell therapy for pediatric cardiomyopathies.
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| Selected Publications: |
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Selected PubMed Publications
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Complete atrioventricular canal: comparison of modified single-patch technique with two-patch technique.
Backer CL, Stewart RD, Bailliard F, Kelle AM, Webb CL, Mavroudis C
The Annals of thoracic surgery 2007 Dec; 84(6):2038-46; discussion 2038-46
PMID: 18036931
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Dual-chamber epicardial pacing in neonates with congenital heart block.
Kelle AM, Backer CL, Tsao S, Stewart RD, Franklin WH, Deal BJ, Mavroudis C
The Journal of thoracic and cardiovascular surgery 2007 Nov; 134(5):1188-92
PMID: 17976448
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Conversion of the failed Fontan circulation.
Backer CL, Deal BJ, Mavroudis C, Franklin WH, Stewart RD
Cardiology in the young 2006 Feb; 16 Suppl 1:85-91
PMID: 16401369
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Trends in vascular ring surgery.
Backer CL, Mavroudis C, Rigsby CK, Holinger LD
The Journal of thoracic and cardiovascular surgery 2005 Jun; 129(6):1339-47
PMID: 15942575
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| Baran, Emily A, Asst Prof in
Emergency Medicine
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| Address: |
Room
100
NMH/259 E Erie
Chicago, IL 60611
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| Phone: |
312/926-9519
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| Baron, Shirley R, Asst Prof, CL in
Psychiatry and Behavioral Sciences
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| E-mail: |
srbaron@nmff.org |
| Address: |
NMH/Onterie Building
Suite
7-100
446 E Ontario
Chicago, IL 60611
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| Phone: |
312-695-2090
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| Interests: |
Sexual dysfunction; Couples therapy; Psychology; Depression; Anxiety disorders
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| Descriptive Phrases: |
As a certified sex therapist, I treat a wide range of sexual disorders, including problems with desire, arousal and orgasm, as well as pain disorders, sexual compulsivity and paraphilias. As a clinical psychologist I also treat individuals and couples with relationship problems, depression and anxiety.
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Barrett, Terrence A, Professor in
Medicine-Gastroenterology
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Affiliated Centers:
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Center for Genetic Medicine
Interdepartmental Immunobiology Center
Robert H. Lurie Comprehensive Cancer Center
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| E-mail: |
tabarrett@northwestern.edu |
| Address: |
Suite
1400
NMH/676 N Saint Clair
Chicago, IL 60611
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| Phone: |
312-695-0182
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| Phone: |
312-695-4065
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| Interests: |
Stem cells; Inflammatory bowel disease; Immunology; Cancer: Colon and Rectal; Immune Regulation
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| Descriptive Phrases: |
The Barrett lab investigates mechanisms of epithelial stem cell activation in mouse and human models of Inflammatory Bowel Disease (IBD). Areas of interest include studying the cooperation between phosphoinositide 3-kinase (PI3K) and Wnt in activating beta catenin signaling (He et al Nat Gen 2007). We find that intestinal inflammation increases PI3K-activated beta catenin in intestinal epithelial progenitor and stem cell populations. We propose that this pathway will be a novel target in strategies for chemoprevention (e.g. colitis-induced cancer) and recovery from radiation-induced stem cell injury (e.g. after nuclear attack). In all projects of the lab we strive to have strong translational components by testing lab-generated hypotheses in patient material.
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| Selected Publications: |
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Selected PubMed Publications
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5-ASA inhibits epithelial beta-catenin activation in chronic ulcerative colitis.
Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, Cheresh P, Blatner NR, Khazaie K, Yang GY, Li L, Barrett TA
Gastroenterology 2009 Oct 28; :
PMID: 19879273
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PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L
Nature genetics 2007 Feb; 39(2):189-98
PMID: 17237784
Grant Support:
R01 DK070001/DK/United States NIDDK
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P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria.
Haddad W, Cooper CJ, Zhang Z, Brown JB, Zhu Y, Issekutz A, Fuss I, Lee HO, Kansas GS, Barrett TA
The Journal of experimental medicine 2003 Aug 4; 198(3):369-77
PMID: 12885868
Grant Support:
AI50837/AI/United States NIAID
K08 GM00709-01/GM/United States NIGMS
P30 DK52574/DK/United States NIDDK
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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Musch MW, Clarke LL, Mamah D, Gawenis LR, Zhang Z, Ellsworth W, Shalowitz D, Mittal N, Efthimiou P, Alnadjim Z, Hurst SD, Chang EB, Barrett TA
The Journal of clinical investigation 2002 Dec; 110(11):1739-47
PMID: 12464679
Grant Support:
DK-38510/DK/United States NIDDK
DK-47073/DK/United States NIDDK
DK-47722/DK/United States NIDDK
DK-48816/DK/United States NIDDK
DK-54778/DK/United States NIDDK
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Selected Books and Book Chapters
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Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. Intestinal Stem Cells in Physiologic Regeneration and Disease. In:
Moody SA, editor.
2007.
Principles of Develomental Genetics.
New York: Elsevier Academic Press 1004-1022.
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Barrett T. A., Snapper S., Blumberg R.. Leukocyte Homing to the Intestine. In:
Sartor R. B., Sandborn W. J., editors.
2003.
Kirsner's Inflammatory Bowel Disease.
London: Saunders 2003 80-89.
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Barsness, Katherine A, Asst Prof in
Surgery
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Affiliated Centers:
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Children's Memorial Research Center (CMRC)
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| Address: |
Children's Memorial Hospital
Box
63
2300 Childrens Plaza
Chicago IL, 60614
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| Phone: |
773-880-4340
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| Phone: |
773-880-4292
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| Interests: |
Surgery; Trauma; Oncology ; Neoplasms; Surgical Education
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| Descriptive Phrases: |
Special interests: Advanced minimally invasive surgery in neonates, infants, children and adolescents including congenital anomalies of the lung, esophagus, diaphragm and intestines; tumors of the chest and abdomen; pyloric stenosis; pectus deformities of the chest; inflammatory bowel disease; splenectomy for hematologic disease.
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| Selected Publications: |
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Selected PubMed Publications
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Laparoscopic Fundoplication After Previous Open Abdominal Operations in Infants and Children.
Barsness KA, St Peter SD, Holcomb GW, Ostlie DJ, Kane TD
Journal of laparoendoscopic & advanced surgical techniques. Part A 2008 Oct 31; :
PMID: 18976126
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Minimally invasive congenital diaphragmatic hernia repair: a 7-year review of one institution's experience.
Shah SR, Wishnew J, Barsness K, Gaines BA, Potoka DA, Gittes GK, Kane TD
Surgical endoscopy 2008 Oct 2; :
PMID: 18830752
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Thoracoscopic patch repair of a right-sided congenital diaphragmatic hernia in a neonate.
Shah SR, Gittes GK, Barsness KA, Kane TD
Surgical endoscopy 2008 Jul 15; :
PMID: 18626698
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Laparoscopic versus open Nissen fundoplication in infants after neonatal laparotomy.
Barsness KA, Feliz A, Potoka DA, Gaines BA, Upperman JS, Kane TD
JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons 2007 Oct-Dec; 11(4):461-5
PMID: 18237511
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Bartles, James R, Professor in
Cell and Molecular Biology
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Affiliated Centers:
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Center for Genetic Medicine
Interdepartmental Immunobiology Center
Northwestern University Institute of Neuroscience (NUIN)
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| E-mail: |
j-bartles@northwestern.edu |
| Address: |
Ward Building
Room
11-185
303 E Chicago Avenue
Chicago IL, 60611
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| Phone: |
312-503-1545
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| Phone: |
312-503-4231
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| Interests: |
Cytoskeleton; Hearing; Cell Biology; Neuroscience ; Molecular Biology; Genetics
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| Descriptive Phrases: |
The research in my lab is centered on the “espins,” a novel family of multifunctional actin-bundling proteins, and the elucidation of their roles in the organization and function of the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. Espins are produced in multiple isoforms from a single gene. They are present at high concentration in the parallel actin bundle of hair cell stereocilia and are the target of deafness mutations in mice and humans. For example, the jerker mutation in the espin gene of mice causes recessive hereditary deafness and vestibular dysfunction accompanied by an abnormal shortening of hair cell stereocilia. Espins are also present at high concentration in the microvilli of taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells, suggesting that these proteins play important, general roles in the microvillar projections of vertebrate sensory cells. Unlike other actin-bundling proteins found in the microvilli and stereocilia of vertebrates, espins are potent actin-bundling proteins that are not inhibited by calcium ion. In cells, espins efficiently elongate parallel actin bundles and, thereby, help determine the steady-state length of microvilli and stereocilia. Espins bind actin monomer via their Wiskott-Aldrich Syndrome protein homology 2 (WH2) domain in vitro and in vivo andcan assemble actin bundles in cells. Certain espin isoforms can also bind phosphatidylinositol 4,5-bisphosphate, profilins or SH3 proteins. These biological activities distinguish espins from other actin-bundling proteins and may make them especially well-suited to sensory cells.
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| Selected Publications: |
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Selected PubMed Publications
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Espin actin-cytoskeletal proteins are in rat type I spiral ganglion neurons and include splice-isoforms with a functional nuclear localization signal.
Sekerková G, Zheng L, Mugnaini E, Bartles JR
The Journal of comparative neurology 2008 Aug 20; 509(6):661-76
PMID: 18551532
Grant Support:
R01 DC004314/DC/NIDCD NIH HHS
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Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells.
Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR
Journal of cell science 2006 Apr 15; 119(Pt 8):1655-65
PMID: 16569662
Grant Support:
GM61010/GM/NIGMS NIH HHS
NS046834/NS/NINDS NIH HHS
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Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.
Loomis PA, Zheng L, Sekerková G, Changyaleket B, Mugnaini E, Bartles JR
The Journal of cell biology 2003 Dec 8; 163(5):1045-55
PMID: 14657236
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The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.
Zheng L, Sekerková G, Vranich K, Tilney LG, Mugnaini E, Bartles JR
Cell 2000 Aug 4; 102(3):377-85
PMID: 10975527
Grant Support:
HD35280/HD/NICHD NIH HHS
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| Battista, Robert A, Asst Prof, CL in
Otolaryngology - Head and Neck Surgery
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| Address: |
Suite
1325
NMH/676 N Saint Clair
Chicago, IL 60611
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| Phone: |
312/503-8920
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| Bayly, Sr., Melvyn A, Professor, Emer in
Obstetrics and Gynecology
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| Address: |
NMH/Prentice Women's Hospital
Room
460
250 E Superior
Chicago IL, 60611
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| Beck, Valerie A, CL Associate in
Pediatrics
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| Address: |
Children's Memorial Hospital
Box
86
2300 Childrens Plaza
Chicago, IL 60614
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| Phone: |
773/880-4549
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Bell, Kimbra A, Asst Prof, CL in
Medicine-General Internal Medicine
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| Address: |
Suite
200
NMH/676 N Saint Clair
Chicago, IL 60611
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| Phone: |
312/695-0917
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Belling, Catherine F, Asst Prof in
Medical Humanities and Bioethics
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| E-mail: |
c-belling@northwestern.edu |
| Address: |
Rubloff Building
Suite
625
750 N Lake Shore
Chicago IL, 60611
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| Phone: |
312-503-3215
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| Interests: |
Medical Humanities; Literature and Medicine; Bioethics; Public Health; Psychiatry; Biomedical Literacy; Narrative Medicine; History of Medicine
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| Descriptive Phrases: |
Hypochondriasis as psychiatric diagnosis; hypochondria/disease anxiety as a problem for primary care; cultural narratives regarding health/disease and their role in fostering anxiety about disease and about health care. The role of narrative in patients', physicians', and biomedical scientists' thinking about the inside of the living human body. The place of fear and uncertainty in medical epistemology.
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| Selected Publications: |
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Selected PubMed Publications
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Hypochondriac hermeneutics: medicine and the anxiety of interpretation.
Belling C
Literature and medicine 2006 Fall; 25(2):376-401
PMID: 17649838
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A window of opportunity: ethics and professionalism in the obstetrics and gynecology clerkship.
Belling C, Coulehan J
Teaching and learning in medicine 2006 Fall; 18(4):326-9
PMID: 17144838
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Imaginary fathers: a sentimental perspective on the question of identifying sperm donors.
Belling C
The Journal of clinical ethics 2005 Winter; 16(4):321-8
PMID: 16447519
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Microbiography and resistance in the human culture medium.
Belling C
Literature and medicine 2003 Spring; 22(1):84-101
PMID: 12795085
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| Bello, Elizabeth A, CL Associate in
Pediatrics
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| Address: |
Children's Memorial Hospital
Box
86
2300 Childrens Plaza
Chicago, IL 60614
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| Phone: |
773/880-4549
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| Belvis, Dawn A, Instructor in
Anesthesiology
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| Address: |
NMH/Feinberg
Room
5-704
251 E Huron
Chicago, IL 60611
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| Phone: |
312/926-2280
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| Bennett, Adam W, Asst Prof, CL in
Family and Community Medicine
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| Address: |
Abbott Hall
710 N Lake Shore Drive
Chicago IL, 60611
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| Interests: |
Sports Medicine; Sports Injuries; Arthritis; Bones,Cartilage, Joints, Muscles
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| Descriptive Phrases: |
I practice primary care sporst medicine. Currently a team physician for the Chicago Bears (NFL) and US Soccer Men's National Team.
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| Selected Publications: |
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Selected PubMed Publications
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The careers of primary care sports medicine physicians in the United States: a survey study.
Bennett A, Lipsky M, Sharp L
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2008 Jan; 18(1):81-4
PMID: 18185044
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| Berger, Susan , Assoc Prof in
Pediatrics
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Affiliated Centers:
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Children's Memorial Research Center (CMRC)
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| E-mail: |
sberger@northwestern.edu |
| Address: |
Children's Memorial Hospital
Box
16
2300 Childrens Plaza
Chicago IL, 60614
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| Phone: |
773-880-8381
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| Interests: |
Health Services Research; Developmental-Behavioral Pediatrics; Graduate Medical Education; Primary Care; Psychology
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| Descriptive Phrases: |
The quality of parent-child relationships during infancy has long-term and significant implications for a child's healthy adaptation. Primary care pediatricians have unique opportunities to support early family relationships because of their repeated encounters with families for well child care. My research and teaching interests have been focused on how emerging parent-infant relationships can be supported by pediatricians and on the impact that the quality of those relationships can have on the practice of primary care pediatrics. In the initial phase of my research, I developed and validated a research protocol for observing and understanding meaningful patterns of interaction that occur between parents and infants during well child visits. Next, I modified the observational system for clinical use, integrated it into Developmental-Behavioral Pediatrics training for pediatric residents and studied its influence on recognition, guidance and documentation in well child care visits. My present interests revolve around exploring mechanisms by which the parent-child relationship may contribute to aspects of child health and behavior that are integral to the provision of comprehensive pediatric primary care. I am currently exploring whether there are pathways that include parent-child relationship quality that predict early childhood obesity. I hope this research will lead to identifying families with children at-risk for early obesity who might benefit from early intervention targeting parent-child interactions, parental sensitivity to infant cues and, more broadly, parent-child relationships in lieu of, or in addition to, traditional interventions for obesity.
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| Berman, Laura A, Asst Prof, CL in
Obstetrics and Gynecology
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| Address: |
NMH/Prentice Women's Hospital
Room
03-2304
250 E Superior
Chicago, IL 60611
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| Phone: |
312/472-3970
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| Bernstein, Richard A, Assoc Prof in
Ken and Ruth Davee Department of Neurology
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| Address: |
Abbott Hall
710 N Lake Shore Drive
Chicago IL, 60611
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| Descriptive Phrases: |
Neurovascular Critical CAre, Stroke
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| Berry, Charles A, Assoc Prof, Emer in
Molecular Pharmacology and Biological Chemistry
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| Address: |
Ward Building
Room
8-296
303 E Chicago Avenue
Chicago, IL 60611
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| Phone: |
312/503-0800
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Bevan, Mark D, Adj Professor in
Physiology
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Affiliated Centers:
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Northwestern University Institute of Neuroscience (NUIN)
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| E-mail: |
m-bevan@northwestern.edu |
| Address: |
Ward Building
Room
5-654
303 E Chicago Avenue
Chicago, IL 60611
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| Phone: |
312-503-4828
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| Interests: |
Neuroscience ; Physiology; Nervous System Diseases; Pharmacology
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| Descriptive Phrases: |
I research the basal ganglia, a group of subcortical brain nuclei that are important for voluntary movement and the primary site of pathology in movement disorders such as Parkinson's disease and Huntington's disease.
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| Selected Publications: |
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Selected PubMed Publications
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Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.
Atherton JF, Wokosin DL, Ramanathan S, Bevan MD
The Journal of physiology 2008 Dec 1; 586(Pt 23):5679-700
PMID: 18832425
Grant Support:
NS041280/NS/NINDS NIH HHS
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Cellular principles underlying normal and pathological activity in the subthalamic nucleus.
Bevan MD, Atherton JF, Baufreton J
Current opinion in neurobiology 2006 Dec; 16(6):621-8
PMID: 17084618
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Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus.
Baufreton J, Atherton JF, Surmeier DJ, Bevan MD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Sep 14; 25(37):8505-17
PMID: 16162932
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Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.
Hallworth NE, Bevan MD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Jul 6; 25(27):6304-15
PMID: 16000620
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| Beyer, Christy A, Instructor, CL in
Obstetrics and Gynecology
|
| Address: |
NMH/Prentice Women's Hospital
Room
03-2304
250 E Superior
Chicago, IL 60611
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| Phone: |
312/472-3970
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Bierman, Jennifer A, Asst Prof in
Medicine-General Internal Medicine
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| Address: |
NMH/Galter
Room
18
675 N Saint Clair
Chicago IL, 60611
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| Descriptive Phrases: |
Preventive medicine, Primary care internal medicine, Women's healthcare
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| Bogey, Ross A, Asst Prof in
Physical Medicine and Rehabilitation
|
| Address: |
Rehabilitation Institute of Chicago
Room
1436
345 E Superior
Chicago, IL 60611
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| Phone: |
312/238-4637
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